![]() Neurofilament light chain (NfL) is a protein located in the cytoplasm of neurons and expressed when axons are myelinated. The results support the potential use of blood biomarkers in measuring the benefits of health behaviors, such as physical activity, and early intervention for older adults at risk for cognitive decline.ĭetermining axonal damage is critical to ensure accurate diagnosis of neurodegenerative conditions. For participants with low NfL concentrations (≤25 pg/mL), those who took part in medium physical activity had 43% slower global cognitive decline (β, –0.025 95% CI, −0.043 to −0.007) and individuals who participated in high physical activity had 30% slower decline (β, –0.031 95% CI, −0.048 to −0.014) than did those who participated in low physical activity (β, –0.046 95% CI, −0.066 to −0.025).Ĭonclusions and Relevance The findings suggest that physical activity is associated with diminished cognitive decline among older adults with increased serum NfL concentrations. Among participants with high NfL concentrations (>25 pg/mL), those who engaged in medium physical activity (<150 minutes per week) had a 12% slower rate of global cognitive decline (SD units, or β, –0.065 95% CI, −0.099 to −0.032) and participants who engaged in high physical activity (≥150 minutes per week) had a 36% slower rate of decline (β, –0.048 95% CI, −0.080 to −0.016) than did participants with low physical activity (no reported participation) (β, –0.075 95% CI, −0.108 to −0.041). Results The study sample included 1158 participants (695 African American 728 female), with a mean (SD) age of 77.4 (6.0) years and a mean educational level of 12.6 (3.5) years. Mixed-effects regression analyses were conducted to examine associations at baseline and longitudinally. ![]() Main Outcomes and Measures Associations of baseline physical activity and NfL concentrations with changes in global cognitive function over time as evaluated using the East Boston Memory Test for episodic memory, the Symbol Digit Modalities Test for perceptual speed, and the Mini-Mental State Examination. Data were analyzed from January to December 2021.Įxposures Self-reported physical activity (minutes per week) and serum NfL concentration (pg/mL). Participants in CHAP who had 2 or more cognitive function assessments and at least 1 blood sample collected for NfL measurement were selected for inclusion in the current study. Objective To examine the association of physical activity and NfL concentrations with cognitive decline in older adults over time.ĭesign, Setting, and Participants This cohort study used data from the Chicago Health and Aging Project (CHAP), a population-based cohort study that recruited participants through door-to-door census in 4 Chicago-area communities and collected data between 19 in cycles of 3 years. Importance Little is known about the association of serum neurofilament light chain (NfL) concentrations and physical activity with the rate of cognitive decline in older adults. Shared Decision Making and Communication. ![]()
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